All must audit.

All of Britain Must Be Stoned!

Distribution: To maintain the integrity and usefulness of cases published in INFORMS Transactions on Education (ITE), distribution of these teaching notes to any other party is prohibited. Please refer interested instructors to ITE for access to the teaching notes. Through an emphasis on data (its collection, analysis, and quality/meaning), this case provides students at the introductory (under...

'In God we trust, all others (must) bring data'.

Mechanisms of Bacterial Transcription Termination: All Good Things Must End.

Transcript termination is essential for accurate gene expression and the removal of RNA polymerase (RNAP) at the ends of transcription units. In bacteria, two mechanisms are responsible for proper transcript termination: intrinsic termination and Rho-dependent termination. Intrinsic termination is mediated by signals directly encoded within the DNA template and nascent RNA, whereas Rho-dependen...

IT security: what all orthopedic surgeons must know.

Orthopedic surgeons rely on technology on a daily basis, from using a practice management system for billing and scheduling to (for some) electronic health records (EHR). Walk in to any education session for orthopedic surgeons and more than half the people in the room have a laptop, iPad® (Apple Inc., Cupertino, California), iPhone®, (Apple Inc.) BlackBerry® (Research in Motion, Waterloo, Onta...

"All Good Things Must Come to an End"

Turning off signaling pathways can be just as important for proper biological regulation as turning them on. The Notch signaling pathway controls development of the nervous system in Drosophila. Proteolysis of Notch appears to initiate signaling, but further proteolysis may also terminate signals from this pathway. Kopan discusses mechanisms that limit signaling by Notch, including recent evide...